diff --git a/src/reaction_generator.py b/src/reaction_generator.py
index c3e8e78..f04ed9f 100755
--- a/src/reaction_generator.py
+++ b/src/reaction_generator.py
@@ -787,6 +787,15 @@ def prime_entity_caches(reaction_connections: pd.DataFrame) -> None:
     # would make the network depend on build order (deltasignal specs/065).
     from src.variant_emission import _sig_cache
     _sig_cache.clear()
+    # So are the structure memos built from those getters (specs/065
+    # amendment 1); caches filled by their own direct query hold database
+    # truth and are kept.
+    import src.logic_network_generator as lng
+    for c in (lng._variant_leafsets_cache, lng._matching_leaves_cache,
+              lng._handoff_leaf_cache, lng._sets_chosen_cache):
+        c.clear()
+    from src import variant_keys
+    variant_keys.reset_caches()
     clear_prefetch_cache()
     reaction_ids = reaction_ids_from_connections(reaction_connections)
     if not reaction_ids:
diff --git a/tests/test_variant_emission.py b/tests/test_variant_emission.py
index a79f869..38bf8bb 100644
--- a/tests/test_variant_emission.py
+++ b/tests/test_variant_emission.py
@@ -251,3 +251,19 @@ def test_priming_a_pathway_clears_set_member_signatures(monkeypatch):
     ve._sig_cache[("M1", True)] = ("stale",)
     rg.prime_entity_caches(None)
     assert ve._sig_cache == {}
+
+
+def test_priming_a_pathway_clears_derived_structure_caches(monkeypatch):
+    # specs/065 amendment 1: every memo computed from the prefetch-limited
+    # getters is per pathway.
+    import src.reaction_generator as rg
+    import src.logic_network_generator as lng
+    monkeypatch.setattr(rg, "reaction_ids_from_connections", lambda rc: ["R1"])
+    monkeypatch.setattr(rg, "prefetch_entity_data", lambda ids: None)
+    caches = (lng._variant_leafsets_cache, lng._matching_leaves_cache,
+              lng._handoff_leaf_cache, lng._sets_chosen_cache,
+              vk._memo, vk._variants_cache, vk._struct)
+    for c in caches:
+        c["stale"] = None
+    rg.prime_entity_caches(None)
+    assert all("stale" not in c for c in caches)